In vitro antioxidant, alpha-glucosidase inhibition and antibacterial properties of turbinaria decurrens bory (Sargassaceae, ochrophyta)

Issue Date

9-2020

Abstract

The genus Turbinaria is a chemically diverse group of seaweeds containing several phytochemicals with unique pharmacological activities useful in the treatment and management of diseases. This study was done to evaluate the bioactive potential of a brown macroalga, Turbinaria decurrens Bory from Pagkalitan, Batangas. The acidified methanolic extract of T. decurrens has a total phenolic content of 27.84 ± 0.12 mg gallic acid equivalents (GAE)/g. Antioxidant efficacy of T. decurrens exerted potent radical scavenging activity against 2-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and 2-diphenyl-1-picrylhydrazyl (DPPH) free radicals as well as high reducing capability of copper ions in a dose-dependent manner with half maximal inhibitory concentration (IC50) value of 49.31 μg GAE/mL, 69.91 μg GAE/mL and 17.2 μg GAE/mL, respectively. In vitro study of α-glucosidase inhibition showed that T. decurrens has potent inhibitory activity (IC50 of 11 μg/mL) as compared to that of acarbose and metformin (anti-diabetic drugs) with IC50 values of 7960 μg/mL and 49.66 mg/mL, respectively. Assessment of the antibacterial activities using microtiter plate dilution assay showed that T. decurrens have strong activity against Methicillin-resistant Staphylococcus aureus, minimum inhibitory concentration (MIC=125 μg/mL) followed by Penicillin-acylase producing Bacillus cereus (MIC=250 μg/mL), Staphylococcus epidermidis (MIC=250 μg/mL), and Pseudomonas aeruginosa (MIC=500 μg/mL). This investigation is one of the pioneering research studies in the Philippines showing the potential of T. decurrens extract as a cheap source of biologically active compounds with potential use for the treatment of drug-resistant bacterial infection and diabetes.

Source or Periodical Title

Asia-Pacific Journal of Science and Technology

Volume

25

Issue

3

Page

1-9

Document Type

Article

Physical Description

tables, references

Language

English

Subject

Algae, Bacterial pathogens, Bioactive compounds, Biological activity, Diabetes, Macroalgae, Philippines, Phytochemicals, Polyphenols, Seaweed, Turbinaria

Identifier

10.14456/apst.2020.30

Digital Copy

yes

En – AGROVOC descriptors

ALGAE; BACTERIAL PATHOGENS; BIOACTIVE COMPOUNDS; BIOLOGICAL ACTIVITY; DIABETES; MACROALGAE; PHILIPPINES; PHYTOCHEMICALS; POLYPHENOLS; SEAWEED; TURBINARIA

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