Fabrication of mica-apatite bioactive glass-ceramics from non-magnetic lahar for in vivo and in vitro testing as possible bone implant in domestic cat

Date

3-2008

Degree

Bachelor of Science in Applied Physics

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Teodorick Barry R. Manguerra

Abstract

on-magnetic lahar was used as the raw material for the mica-apatite bioactive material of system Si02-A103-CaO-MgO-K20-P205 with glass formulation of 50.41, 3.37, 6.68, 14.61, 13.34 and 2.6 weight percentages, respectively. The glass-ceramics were subjected to in vivo test by implanting the material into the shaft of the right femur of two male domestic cats (Fells catus domesticus) aged between 8 months to 2 years. In thirteen days of surgery, radiography of the hind limb at the level of the os coxae of the cats showed that the material was displaced on the muscle tissue of the hind limb. Ultrasonographic images of the hind limbs illustrated that there was no inflammation in the surrounding tissues where the implant material was located. Physical condition of the wound presented healing with no pus formation and inflammation. Complete Blood Count of the cats showed no dramatic change in blood chemistry. The cats were able to proceed with normal activities. The glass-ceramics were also subjected to in vitro test by soaking the samples in SBF at 37 °C for one, three and five days. SEM of the soaked glass-ceramic material showed the formation of Hydroxy Carbonate Apatite layer. With the results of the in vitro and in vivo test, mica-apatite bioactive glass-ceramics from non-magnetic lahar is a possible alternative material for bone implant.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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