Electrospun nanofibrous scaffold from polycaprolactone (PCL)/polyethylene oxide (PEO)

Date

3-2008

Degree

Bachelor of Science in Applied Physics

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Teodorick Barry R. Manguerra

Abstract

Polycaprolactone (PCL)/Polyethylene Oxide (PEO)/lota Carrageenan (WAR) Blends. Thesis Adviser: Teodorick Barry R. Manguerra Polycaprolactone (PCL)/Polyethylene Oxide (PEO)/lota Carrageenan (tCAR) nanofibrous scaffold was fabricated using electrospinning. Characterization was done using Scanning Electron Microscopy (SEM) and Fourier Tansform — Infrared Spectroscopy (FT-1R). The effect of tip to collector distance was determined using distances of 10 centimeters, 15 centimeters, and 20 centimeters. The effect of PEO/tCAR ratio was determined using 3 solutions, namely, 0.30 grams PCL/0.45 grams PEO/0.25 grams tCAR, 0.30 grams PCL/0.35 grams PEO/0.35 grams tCAR, and 0.30 grams PCL/0.25 grams PEO/0.45 grams tCAR ratios. The nanofibrous scaffold was also tested for degradation through in vitro treatment using Simulated Body Fluids (SBF) solution. Results showed a correlation between the tip to collector distance and fiber diameter of the scaffold. As distance from tip to collector increased, the diameter of the fiber decreased. It was also observed that as PEO amount was increased, fiber diameter also increased, while as the tCAR amount was increased, fiber diameter decreased. FT-IR Spectrograph analysis showed that the compounds present in the scaffold were also present in PCL, PEO, and tCAR. It was observed that the nanofibrous scaffold was degraded after a 24-hour immersion in the SBF solution. Although a nanofibrous scaffold was produced, it was found that the scaffold had defects such as bead formation and melt. There was a wide range in the diameter of the fibers produced due to the lack of flow rate control.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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