An investigation on the variation of cellular energy with growth for B16 melanoma using energetic balance model

Date

3-2005

Degree

Bachelor of Science in Applied Physics

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Chrysline Margus N Piñol

Abstract

The relationship of cellular energy with B16 melanoma growth was investigated using the Castorina-Zappala energy model and the Norton-Simon model. An equation as a function of cellular energy was derived for B16 Melanoma. The tumor system was assumed to be a multicellular tumor spheroid (MTS) composed of proliferating and non-proliferating cells that follows a Gompertzian growth. For each solution set of state, minimum cellular energy e , and energy gap 6, simulated tumor volume, N(t), were calculated. The best value for N(t) was obtained by calculating the mean and the standard error. The mean was compared to the computed B16 melanoma data and a percentage error of 5% was obtained. The relative error was calculated using the mean and the standard error. Results showed 0.91% relative error. These observations show that the approximate solutions of , and 6 were optimized using the genetic algorithm. From the computations of the mean cellular energy, it can be concluded that as the N(t) increased the cellular energy Ej decreased.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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