Preliminary study on the effects of paraquat on guinea pig (Cavia porcellus) liver mitochondrial dehydrogenase activity

Date

3-1976

Degree

Bachelor of Science in Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

William G. Padolina

Abstract

ABSTRACT Hedreyda , Cynthia Trinidad , College of Sciences and Humanities University of the Philippines at Los Banos, March 1976. Preliminary study on the Effects of Paraquat on Guinea Pig (Cavia porcellus) Liver Mitochondrial Dehydrogenase Activity. Adviser: Dr. William Padolina.

This study was conducted to determine the effects of the herbicide paraquat (1-1'- dimethyl - 4-4'-bipyridium salt) on (guinea pig liver mitochondrial dehydrogenase activity which was measured by means of dye (DPIP) reduction technique. Liver mitochondrial dehydrogenase activity was enhanced when paraquat was administered in vitro.. Paraquat may contribute to the total dye reduction as an efficient intermediate electron acceptor end donor. No definite conclusion could be derived from the observation that paraquat caused the very slight inhibition of liver mitochondrial dehydrogenase activity when administered in vivo. This may be due to the spread of the compound to the various parts of the body, elimination, and poor herbicide penetration into tissues.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

This document is currently not available here.

Share

COinS