Preliminary study on the effect of Trichlorfon on liver mithochondrial succinate dehydrogenase activity in guinea pig (Cavia sp.)

Date

3-1984

Degree

Bachelor of Science in Biology

Major Course

Major in Cell Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

William G. Padolina

Abstract

Mitochondria from guinea pig liver were treated with trichlorfon both in vitro and in vivo. The rate of mitochondrial succinate dehydrogenase activity was measured using DPIP dye-reduction technique. In vitro, treatment with trichlorfon produced significant inhibition of succinate dehydrogenase with the degree of inhibition increasing with the dosage of trichlorfon applied. The possible cause of inhibition is the conversion of trichlorfon into a strong toxicant, dichlorvos which can alter the succinate dehydrogenase structure causing lost of its catalytic function. In vivo study showed no significant effect on succinate dehydrogenase activity, may be due to rapid degradation and elimination of trichlorfon.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

UPLBUT-5804

Document Type

Thesis

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