Macroscopic and Microscopic Comparison of Wound Healing in Surgical Incisions in Dogs (Canis lupus familiaris) Using Autologous Serum and Mupirocin Ointment

Date

2024

Degree

Doctor of Veterinary Medicine

Adviser/Committee Chair

Rey B. Oronan

Co-adviser

Marco F. Reyes

Abstract

Background: Autologous serum, naturally enriched with growth factors, vitamins, and immunoglobulins, is a known alternative to artificial tears for treating ocular surface injuries. Such is derived from a patient's own blood. Its efficacy extends beyond lubrication offering potential benefits in enhancing wound healing, and post-operative care. Although it shares a composition similar to natural tears and contains essential wound healing factors, its potential for treating skin wounds has not been extensively studied. This study aims to see if it could be a useful alternative to current treatments, like mupirocin ointment. Methods: Six apparently healthy, adult female, non-descript, dogs for ovariohysterectomy were used for the study. All dogs had two incisions (one from the surgical procedure), one treated with autologous serum, and the other treated with mupirocin ointment. The dogs were divided into two collection days, day 7 and day 14, to elucidate on the macroscopic and microscopic changes in wound healing. Results: There is no sufficient evidence to say that the scores for both macroscopic and microscopic examinations are different between the two treatments. Both also proved to show more desired wound healing responses, mitigating observed exacerbations in excessive healing. Conclusion: The results strongly suggest the efficacy of autologous serum as an effective alternative in accelerating the skin wound healing process.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Awards: Enrique Carlos Jr. Best Undergraduate Thesis Award on the Dog and Cat

Document Type

Thesis

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