Effects of sambong [Blumea balsamifera (L.) DC.] aqueous leaf extract on the internal organs of white mice (Mus musculus BALB/C

Date

3-1988

Degree

Bachelor of Science in Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Ludivina S. De Padua

Abstract

The gross morphological and histological effects of varying concentrations of sambong (Blumea balsamifera (L.) DC. ) leaf extract on the internal organs of adult white male mice (Mus musculus BALB/C)) was determined. The three treatment groups evaluated were distilled water, 10% sambong leaf extract and 20% sambong leaf extract in distilled water, given for a period of four weeks. The weights (expressed in mg/gm body weight) of the internal organs (liver, kidneys, spleen, testes, small intestine, large intestine, and heart) were not significantly affected by the sambong leaf extract. It was observed that 0.25 ml of 10% and 20% sambong leaf extracts given daily for four weeks through the gavage method caused significant effects in the liver (cloudy swellings, edema, and necrosis), small intestine (fatty changes, slough-off mucosa, and pyknoses of the nuclei), and the large intestine (severe fatty changes). The 10% and 20% sambong leaf extract were concluded to e beyond the safe dosage.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

This document is currently not available here.

Share

COinS