Effect of a commercial food supplement on the serum uric acid, creatinine and urea concentrations in mature Sprague Dawley rats

Date

4-2006

Degree

Bachelor of Science in Chemistry

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Nieva T. Librojo-Basilio

Co-adviser

Teofila DC Villar

Committee Member

Veronica C. Sabularse

Abstract

Quantitative analyses of the serum uric acid, creatinine and urea nitrogen concentrations of sixteen mature Sprague Dawley rats were conducted to determine the possible effects of different dosages of the commercial food supplement after the one-week administration. The growth and behavior of the rats were noted before and after feeding the commercial food supplement. It was observed that the rats in the control group behaved normally but most of the rats treated with the food supplement showed some positive behavioral changes. Using univariate analysis of variance and one-way ANOVA, it was found that the different dosages of the food supplement affected the creatinine and urea nitrogen at p< 0.05 but not the uric acid. Comparison between the mean differences of the two dosages was done statistically using least significant difference (LSD) test. Although there was no significant difference between the mean creatinine concentrations of the control and the 0.04 g treatment, the mean concentration of the latter was lower. Results showed that the mean creatinine, urea nitrogen and the uric acid concentrations were lower among the treated rats than those of the rats in the control group. But there was no observed trend with the increase in the dosages of the food supplement because of some possible factors such as initial health conditions of the rats before the treatment, the hypersensitivity or hyposensitivity of the rats, contamination of the food and water supply, and the dehydration. It was found that the mean concentrations of the creatinine and urea nitrogen were directly proportional. This was observed due to the association of these two waste products with the kidney function. Ibis study showed that the commercial food supplement helped decrease the Incas creatinine. urea nitrogen, and uric acid concentrations.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

LG 993.5 2006 C4 M34

Document Type

Thesis

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