Studies on the preparation of carboxymethyl celluloses from nata de coco and their use in drug delivery

Date

3-1998

Degree

Bachelor of Science in Chemistry

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Evelyn B. Rodriguez

Co-adviser

Maxima E. Flavier

Abstract

ABSTRACT

PADOLINA, IBARRA D., B.S. Chemistry, University of the Philippines at Los Banos, March 1998, " Studies on the Preparation of Carboxymethyl Celluloses from Nab de Coco and their Use in Drug Delivery". Adviser: Dr. Evelyn B. Rodriguez

Carboxymethyl celluloses were prepared from nom cellulose powder by crosslinking with formaldehyde and hydrochloric acid, then carboxymethylation by refluxing with chloroacetic acid. Two treatments were done, producing carboxymethylated materials labelled X-CMC I and X-CMC2. Non-crosslinked cellulose was also carboxymethylated yielding a water-soluble product labelled NX- CMC I.

The carboxymethyl celluloses were characterized in terms of degree of substitution (DS) and IR spectroscopy. The average degrees of substitution of commercial CMC, non-crosslinked nolo, crosslinked ?rata, NX-CMC I, X-CMC1 and X-CMC2 were found to be 0.71, 0.16, 0.18, 0.83, 0.83, and 1.27, respectively. The IR spectra of X-CMC1 and X-CMC2 showed peaks at 1608.96 cm-1 and 1420.90 cm-1 that are characteristic of the carboxylate group. These peaks were absent from the spectrum of the crosslinked flaw. This indicated the successful introduction of the carboxymethyl group in cellulose.

X-CMC1, which was the least soluble in water compared to the other derivatives, was tableted using acetaminophen (APAP) as the active ingredient.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

LG 993.5 1998 C4 P34

Document Type

Thesis

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