Effects of a commercial food supplement on the serum total cholesterol, fasting blood sugar and triglyceride levels in male Sprague Dawley rats

Date

10-2006

Degree

Bachelor of Science in Chemistry

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Nieva T. Librojo-Basilio

Abstract

SARIO, GABRIEL MALONZO, College of Arts and Sciences, University of the Philippines Los Banos, October 2006. EFFECTS OF A COMMERCIAL FOOD SUPPLEMENT ON THE SERUM TOTAL CHOLESTEROL, FASTING BLOOD SUGAR AND TRIGLYCERIDE LEVELS IN MALE SPRAGUE-DAWLEY RATS.

Adviser: Dr. Nieva T. Librojo-Basilio

The possible effects of a commercial food supplement on the concentrations of serum total cholesterol, triglyceride and fasting blood sugar were determined. Twenty seven male Sprague Dawley rats with ages ranging from 16-18 weeks were grouped into four and each fed with different levels of the food supplement (0.000g, 0.0138g, 0.0275g, and 0.0550g) in the morning and evening for seven consecutive days. Their body weights were determined at the start, on the fourth day, and on the last day before sacrifice. The rats were sacrificed after seven days of oral administration of the food supplement. The total cholesterol, triglyceride and fasting blood sugar in blood serum were quantitatively analyzed.

Results of the experiments showed that there was an overall increase in the average weight of rats in each group in all the treatments.

The means of the total cholesterol, triglyceride and fasting blood sugar concentrations in the different levels of food supplement were statistically compared using one-way analysis of variance. Results of the total cholesterol mean concentrations showed that there was a significant difference between the control and those treated with the food supplement (P60.05). For the triglyceride and fasting blood sugar mean concentrations, there were significant differences between the means of the three treatments and the control group (P50.01). However, there were no significant differences observed among those that were fed with different levels of the food supplement.

Using Duncan's Multiple Range Test, the mean fasting blood sugar level of the rats treated with 0.0550g food supplement was significantly lower than that of the control rats. Results showed that there was a significant positive linear correlation between the levels of serum cholesterol, triglyceride, and fasting blood sugar levels of rats.

The lowering of serum total cholesterol, triglyceride, and fasting blood sugar means concentrations was observed in rats fed with the food supplement. Results of the study showed that the food supplement has benefits and can help promote or boost good health.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

This document is currently not available here.

Share

COinS