Analgesic activities of the aqueous body wall extract and coelomic fluid of Synapta maculata (Chamisso and Eysenhardt, 1821)

Date

4-2010

Degree

Bachelor of Science in Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Dalisay Giron-Maligalig

Abstract

The analgesic property of the aqueous body wall (BW) and coelomic fluid (CF) extracts of Synapta maculata (Chamisso and Eysenhardt, 1821) was evaluated using the abdominal writhing method for slow pain, and the tail flick method for fast pain. Experimental set-ups were prepared for each bioassay and extract using 250 mice randomly distributed (n=5). Each set-up includes five groups given with 0, 50, 75, 100mlkg-1 of the extracts; and a standard-morphine group (intraperitoneal - 0.8 mgkg-1 and oral - 5.0 mgkg-1 , for abdominal writhing and tail flick, respectively). Analgesic potential was further assessed using Percent Inhibition for slow pain and Maximum Possible Analgesia for fast pain. Results in both methods suggest that the analgesic property of BW is comparable to that of morphine. However the effect is not dose- dependent. The CF extract groups were also able to inhibit contractions, but all concentrations exhibit weaker effect than morphine. Comparison of the analgesic activity of BW and CF extracts in the abdominal writhing (p<0.0001) and tail-flick (p<0.01) methods provides evidence that BW of S. maculata is effective in relieving both slow and fast pain.

Language

English

Location

UPLB Main Library Special Collections Section

Document Type

Thesis

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