Date

2021

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Marco F. Reyes, Rey B. Oronan

Abstract

This study described the macroscopic and microscopic lesions, and frequency of silver ion deposition in the kidneys of female ICR mice upon oral administration of colloidal silver. Fifty samples were divided into a total of six treatment groups: two control groups (n=5) given 3DH2O (0.07mL), two low dose treatment groups (n=10) given 0.07mL colloidal silver solution, and two high dose treatment groups (n=10) given 0.12mL colloidal silver solution, each with durations of seven or 14 days. No macroscopic lesions were observed. Histopathology revealed glomerulonephritis as the most common microscopic lesion, followed by congestion and fibrosis. Tubular hypertrophy due to compensatory mechanism of the kidneys were found in groups treated for seven days, while longer duration of treatment led to tubular atrophy and necrosis. Protein and hemosiderin were also found in select samples. Silver ion deposition occurred due to the slow excretion of silver ions in the kidneys. Visualized as black pigments within the renal tubules, this occurred more frequently with prolonged treatment duration and increased dose of treatment. The increase in dose and duration of colloidal silver administration led to various toxic changes, deterioration of normal renal architecture, and renal tubular cell death.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Best Thesis in Veterinary Pathology, 2021

Document Type

Thesis

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