Date

2021

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Maria Amelita C. Estacio, Mark Joseph M. Desamero

Abstract

The carrageenan-induced hind paw edema model in mice was used to further elucidate the anti-inflammatory activity of honey and propolis from the Philippine stingless bee (Tetragonula biroi Freise). Injection of the phlogistic agent, λ-carrageenan, in mice resulted in significant 11-fold and 7-fold increase in blood levels of interleukin 1β (IL-1β) and IL-6, respectively compared with the healthy non-treated mice. Remarkably, pre-treatment with Philippine stingless bee honey significantly reduced blood levels of IL-1β by 38.46% and IL-6 by 36.75%, respectively in carrageenan-injected mice. Similarly, pre-treatment with Philippine stingless bee propolis reduced blood levels of IL-1β and IL-6 by 41.12% and 50.78%, respectively. This aforementioned reduction in blood IL-1β and IL-6 levels with honey and propolis treatment were statistically comparable with the anti-inflammatory drug, diclofenac sodium. These findings indicate that the Philippine stingless bee honey and propolis possess potent anti-inflammatory activity through inhibition of the pro-inflammatory cytokines, IL-1β and IL-6. Altogether, it strengthens the potential development of these indigenous bee-derived substances as new biomedical products for the treatment of acute inflammatory conditions.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Most Innovative Undergraduate Thesis Award on Veterinary Medicine, 2021

Document Type

Thesis

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