Acute inflammatory increase in interleukin 1β and interleukin 6 in λ-carrageenan injected ICR mice attenuated by topical treatment of Philippine stingless bee [Tetragonula biroi (Friese)] honey

Date

2022

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Abstract

The Philippine stingless be [Tetragonula biroi (Friese)] industry has been established for decades now, yet literature surrounding the therapeutic effects of its honey remain to be sparse. In recent years, the anti-inflammatory effects of T. biroi (Friese) have been investigated and established. Herein, we inforce the proven anti-inflammatory action of topically-applied Philippine stingless bee honey on the λ-carrageenan-induced hindpaw edema model through the suppression of pro-inflammatory cytokines IL-1β and IL-6. Twenty (20) 6-week-old male ICR mice were divided into four (4) groups (n=5 per group) as follow: non-treated group, normal saline solution group, diclofenac sodium (10 mg/kg) group, and the Philippine stingless bee honey (100 mg/kg) group. Following injection with λ-carrageenan across all groups, the corresponding treatment per group was administered every 8 hours within a 24-hour time frame and blood IL-1β and IL-6 were measured afterwards. The results showed that topically applied Philippine stingless bee honey, as compared to diclofenac sodium, equipotently attenuated inflammation through reduction of the pro-inflammatory cytokines IL-1β and IL-6 bu 48.8% and 59.4%, respectively.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Document Type

Thesis

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