Reduction of IL-1β and IL-6 Blood Levels with Topical Administration of Philippine Stingless Bee Tetragonula biroi (Friese, 1898) Propolis in Carrageenan-induced Mouse Hind Paw Edema

Date

2022

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Abstract

The carrageenan-induced hind paw model in mice was used to clarify the anti-inflammatory property of propolis from Philippine stingless bees [Tetragonula biroi (Friese, 1898)]. Injection of the phlogistic agent λ-carrageenan resulted in a remarkable 11-fold and 9-fold increase in interleukin 1β (IL-1β) and IL-6 blood plasma levels compared with healthy non-treated mice, respectively. Topical post-treatment of Philippine stingless bee propolis resulted in a decrease in IL-1β and IL-6 plasma levels at 55.96% and 66.31%, respectively. This significant finding was statistically comparable with an anti-inflammatory drug, diclofenac sodium. Thus, proving that Philippine stingless bee propolis possess anti-inflammatory activity that is mediated through the suppression of pro-inflammatory cytokines, IL-1β and IL-6.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Award: Compania J. M. Inc. Best Undergraduate Thesis Award in Veterinary Pharmacology

Document Type

Thesis

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