Synergistic increase in antibiotic resistance with tolerance to cadmium and lead in environmental bacteria isolated from the San Cristobal River, Laguna De Bay, Philippines

Issue Date

11-2020

Abstract

Pollution increases bacterial tolerance to heavy metals and antibiotic resistance. San Cristobal River sediment and water samples were analysed for Cadmium (Cd) and Lead (Pb). Isolates of Salmonella spp. and Vibrio spp. were tested for tolerance to metals and resistance to five different classes of antibiotics. Isolates showing tolerances to Cd were linked to increased resistance to antibiotics (76.5%) compared to Pb-tolerant isolates (66%). Tolerance to both Cd and Pb further increased antibiotic resistance (p < 0.05). Cd-tolerance correlated with resistance to Amp, Sxt and Cip while Pb tolerance correlated with resistance to C, Amp and Cip. These results support a bacterial mechanism whereby transfer of plasmids expressing metal tolerance promotes increased antibiotic resistance.

Source or Periodical Title

International Journal of Environmental Studies

ISSN

0020-7233

Volume

78

Issue

1

Page

165-183

Document Type

Article

Physical Description

illustration, graphs, map, tables

Language

English

Subject

antibiotics, Bacteria, metals, resistance, River, tolerance

En – AGROVOC descriptors

BACTERIA; ANTIBIOTICS; METALS; RESISTANCE; TOLERANCE; RIVER

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