The in vitro and in vivo protective effects of tannin derivatives against Salmonella enterica serovar Typhimurium infection

Issue Date

8-2017

Abstract

In this study, we investigated the protective effects of tannin-derived components, gallic acid (GA) and tannic acid (TA), in vitro and in vivo against Salmonella infection in mice. Both GA and TA showed antibacterial effects against Salmonella (S.) Typhimurium as well as inhibitory effects on the adherence, invasion, and intracellular growth of the pathogens in macrophages. Following a lethal dose of Salmonella infection in mice, reduced virulence in both GA- and TA-treated groups was observed based on reduced mortality rates. In the non-infected groups, the average weights of the spleens and livers of GA- or TA-treated mice were not significantly different with the control group. In addition, the average weights of these organs in all of the Salmonella-infected groups were not significantly different but the numbers of bacteria in the spleens and livers in both GA- and TA-treated mice were significantly reduced. The levels of cytokine production in non-infected mice revealed that GA-treated and TA-treated mice elicited an increased level of IFN-γ, and both IFN-γ and MCP-1, respectively, as compared with the PBS-treated group. These findings highlight the potential of GA and TA as alternatives for the treatment of salmonellosis and as supplements to conventional antimicrobial food additives.

Source or Periodical Title

Microbial Pathogenesis

ISSN

8824010

Volume

109

Page

86-93

Document Type

Article

Physical Description

illustrations, graphs

Language

English

Subject

Antibacterial, Gallic acid, Salmonella Typhimurium, Tannic acid

Identifier

https://doi.org/10.1016/j.micpath.2017.05.034

Digital Copy

yes

En – AGROVOC descriptors

Salmonella Typhimurium; Gallic acid; Tannic acid; Antibacterial

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