First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines
Issue Date
6-2017
Abstract
Pteropine orthoreovirus (PRV) causes respiratory tract illness (RTI) in humans. PRVs were isolated from throat swabs collected from 9 of 91 wild bats captured on the Mindanao Islands, The Philippines, in 2013. The nucleic acid sequence of the whole genome of each of these isolates was determined. Phylogenetic analysis based on predicted amino acid sequences indicated that the isolated PRVs were novel strains in which re-assortment events had occurred in the viral genome. Serum specimens collected from 76 of 84 bats were positive for PRV-neutralizing antibodies suggesting a high prevalence of PRV in wild bats in the Philippines. The bat-borne PRVs isolated in the Philippines were characterized in comparison to an Indonesian PRV isolate, Miyazaki-Bali/2007 strain, recovered from a human patient, revealing that the Philippine bat-borne PRVs had similar characteristics in terms of antigenicity to those of the Miyazaki-Bali/2007 strain, but with a slight difference (e.g., growth capacity in vitro). The impact of the Philippine bat-borne PRVs should be studied in human RTI cases in the Philippines.
Source or Periodical Title
Archives of Virology
ISSN
0304-8608
Volume
162
Issue
6
Page
1529-1539
Document Type
Article
Physical Description
illustrations, tables, graphs
Language
English
Recommended Citation
Taniguchi, S., Maeda, K., Horimoto, T., Masangkay, J.S., Puentespina, R., Alvarez, J., Eres, E., Cosico, E., Nagata, N., Egawa, K., Singh, H., Fukuma, A., Yoshikawa, T., Tani, H., Fukushi, S., Tsuchiaka, S., Omatsu, T., Mizutani, T., Une, Y., Kyuwa, S. (2017). First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines. Archives of Virology, 162 (6), 1529-1539.
Identifier
DOI:10.1007/s00705-017-3251-2
Digital Copy
yes