Acute oral toxicity of lansioside D in mice
Issue Date
1-2016
Abstract
Lansioside D is a novel antimicrobial compound isolated from the peel of Lansium domesticum. This compound has a very remarkable activity against Gram-positive bacteria including Methicillin-resistant Staphylococcus aureus (MRSA). For the initial phase towards its development as a potential drug, a study to determine its acute oral toxicity was conducted. Forty male and 40 female ICR mice were equally distributed into three treatment groups and one control group. The treatment groups were administered with Lansioside D at various dose levels: 31.25 mg/kg body weight (low dose), 500 mg/kg body weight (middle dose) and 1000 mg/kg body weight (high dose). The control group was administered only with distilled water. Mortality within a 24-h period, as well as daily monitoring of food intake, water intake and body weight 14 days after the administration of the compound was done. Creatinine, urea nitrogen (BUN) and alanine aminotransferase (ALT) levels were also determined prior to treatment (day 0), on day 7 and on day 14. At the end of the 14-day observation period, animals were sacrificed and dissected. The stomach, kidneys and liver were isolated, their gross morphology and relative organ weights were determined, and thereafter subjected to histological evaluation. Results showed no mortalities after 24 h and no differences in all daily observed physiological parameters. Blood creatinine, BUN and ALT levels were normal prior up until the end of the experimentation. No differences were observed in the gross morphology of the stomach, kidneys and liver, as well as the relative organ weights among all the treatment and control groups. Histological examination of these organs revealed no significant abnormal findings. The above results suggest that Lansioside D is not toxic to mice and therefore has a potential to be developed as a new antibiotic.
Source or Periodical Title
International Journal of Toxicological and Pharmacological Research
Volume
8
Issue
2
Page
70-77
Document Type
Article
Physical Description
illustrations, tables, graphs
Language
English
Subject
Lansioside D, Lansium domesticum, Lansones, Toxicity
Recommended Citation
Marfori, P.A.N., Maligalig, M.D.G., Estacio, M.A.C., Cena, R.B., Desamero, M.J.M., Ang, M.J.C., Marfori, E.C. (2016). Acute oral toxicity of lansioside D in mice. International Journal of Toxicological and Pharmacological Research, 8 (2), 70-77.
Digital Copy
yes