Acute oral toxicity of trichosetin in mice (Mus musculus L.)

Issue Date

1-2015

Abstract

This study characterizes the toxicity profile of trichosetin, a novel drug which showed pronounced activity against methicillin-resistant Staphylococcus aureus (MRSA). Different doses of this drug were orally administered to male and female ICR-strain Swiss Webster mice. Characterization of toxidromes was executed during a 14-d observation period. Gross examination of the liver, heart, spleen, kidneys, and lungs of mice was performed at the termination of the study. Trichosetin showed a dose-related increase in the magnitude of biological response observed in the toxidromes and body weights of mice. However, no dose-related changes were observed in the weight and gross morphological anatomy of the major internal organs of mice. The median effective dose (ED 50 ) for analgesia was 325.1 ± 71.7 mg kg -1 . The median toxic dose (TD 50 ) for dyspnea was 417.6 ± 67.4 mg kg -1 . The No Observed Adverse Effect Level (NOAEL) of trichosetin was 160 mg kg -1 under the conditions of this study. The results of this study suggest that the possible target organ system of trichosetin toxicity is the central nervous system, which exhibited the most number of toxidromes.

Source or Periodical Title

Philippine Journal of Science

ISSN

0031-7683

Volume

143

Issue

2

Page

99-106

Document Type

Article

Physical Description

illustrations, tables, graphs

Language

English

Subject

Antibiotic, Cleaning, Dual culture, MRSA, Toxicity, Trichosetin

Digital Copy

yes

Link to Full Text

Share

COinS