Formulation of larvicide from Capsicum frutescens (Linn.) fruit extract against Aedes aegypti (L.)

Issue Date

9-2020

Abstract

The crude ethanolic extract of Capsicum frutescens fruit was used in the formulation of larvicidal granules. The extract was first screened for phytochemical content and larvicidal activity against Aedes aegypti. Five trial formulations were developed using different combinations of excipients identified to be compatible with the active extract. These formulations were evaluated using Quality by Testing (QbT) Method (organoleptic evaluation, moisture content, powder flow property, particle size distribution, dissolution in water and larvicidal bioactivity). The C. frutescens extract (500 ppm) killed 100% of the test larvae after 24 and 48 h. Phytochemical analysis revealed the presence of steroids, indoles, alkaloids, flavonoids, sugars, coumarins and anthraquinones. Among the formulations tested, formulation # 5 (25% extract, 59% lactose, 1% 5% PVP-ethanol solution, and 15% microcrystalline cellulose (MCC) was the most active, with LC50-24 h=108.68 ppm, LC90-24 h=233.44 ppm, LC50-48 h=102.68 ppm, and LC90-48 h=182.50 ppm. Larvicidal granules (Formulation #5) against A. aegypti were developed. The granules were able to kill 100% of the test larvae after 24 and 48 h of exposure. In addition, the formulation passed all the quality control measurements (low moisture content, excellent powder flow, soluble in water, and 90% cumulative frequency within 0.420-0.841 mm).

Source or Periodical Title

Philippine Agricultural Scientist, The (Formerly the Philippine Agriculturist)

ISSN

0031-7454

Volume

103

Issue

3

Page

207-213

Document Type

Article

College

College of Agriculture and Food Science (CAFS)

Frequency

quarterly

Physical Description

illustration; graph; tables; references

Language

English

Subject

Insecticides; Pest control; Plant extracts

En – AGROVOC descriptors

CAPSICUM FRUTESCENS; AEDES AEGYPTI; BIOCHEMISTRY; FORMULATIONS; INSECTICIDES; VECTORBORNE DISEASES; PEST CONTROL; FRUITS; PLANT EXTRACTS

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