"Quantitative trait locus analysis of serum insulin, triglyceride, tota" by Rea Victoria P. Anunciado, Masahiko Nishimura et al.
 

Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J × A/J)F2 mice

Abstract

Quantitative trait locus (QTL) analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels at 10 weeks of age was performed in 321 F2 offspring from SM/J and A/J mice. Interval mapping revealed a total of 22 suggestive QTLs affecting the four traits: two insulin QTLs on Chromosomes (Chrs) 6 and 8; six triglyceride QTLs on Chrs 4, 8, 9, 11, 12 and 19; six total-cholesterol QTLs on Chrs 1, 3, 4, 14, 17 and 19; and eight phospholipid QTLs on Chrs 2, 3, 4, 6, 8, 10 and 19. Gender influenced the expression of eight of the suggestive QTLs. The total-cholesterol QTLs on Chrs 4, 14 and 17, the triglyceride QTL on Chr 9 and the phospholipid QTL on Chr 4 were specific to females. The phospholipid QTLs on Chrs 2 and 6 and the insulin QTL on Chr 8 were specific to males. In addition, common QTL involved in the regulation of some of the traits were identified. The female-specific OTL on Chr 4 appeared to be involved in the regulation of total cholesterol and phospholipid levels. The QTL on Chr 8 affected insulin and phospholipid levels, whereas the Chr 19 OTL was common to the three lipid parameters. Copyright © 2003 Japanese Association for Laboratory Animal Science.

Source or Periodical Title

Experimental Animals

ISSN

13411357

Page

37-42

Document Type

Article

Subject

Insulin, Interval mapping, Lipids, Quantitative trait loci (QTLs)

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