IL-17A treatment influences murine susceptibility to experimental Riemerella anatipestifer infection

Issue Date

5-2020

Abstract

Riemerella anatipestifer causes infectious disease and considerable economic loss in the duck industry worldwide. Our previous studies demonstrated an association between proinflammatory cytokine interleukin (IL)-17A and R. anatipestifer infection. Here, we provide evidence for IL-17A involvement in R. anatipestifer infection using a mouse model. Mice showed higher resistance to R. anatipestifer infection than ducks, with median lethal doses (LD50) of 3.5 × 1010 and 5 × 107 colony-forming units (CFU), respectively. Twenty-four hours after infection, mice with a sub-lethal dose (3.5 × 109 CFU) exhibited levels of IL-17A and IL-23 expression similar to uninfected mice. Thus, we hypothesized that exogenous IL-17A or IL-23 administration affects susceptibility of mice to R. anatipestifer. Mice pretreated with IL-17A or IL-23 prior to sub-lethal dose infection of R. anatipestifer exhibited increased bacterial burden and spleen weights compared to untreated infected mice, confirming the involvement of IL-17A in susceptibility to R. anatipestifer infection in vivo.

Source or Periodical Title

Developmental and Comparative Immunology

ISSN

0145-305X

Volume

106

Page

103633

Document Type

Article

Physical Description

graph; table; references

Language

English

Subject

Ducks, IL-17A, IL-23, Mouse model, Riemerella infection, Susceptibility

Identifier

DOI:10.1016/j.dci.2020.103633

Digital Copy

Yes

En – AGROVOC descriptors

RIEMERELLA INFECTION; MOUSE MODEL; IL-17A; IL-23; SUSCEPTIBILITY; DUCKS

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