Fate of 14C-carbofuran in lactating goats

Abstract

Radiocarbon labelled carbofuran was administered orally to lactating goats at 0.03 mg/kg (single dose), 0.5 and 1.0 mg/kg/day for 7 days and 5.0 ppm in the diet (2 kg intake/day basis) for 15 days. Radioactive residues were rapidly excreted in the urine after treatment. The major residues identified in urine of the treated goats was carbofuran phenol, a non-toxic metabolite. Only about 1% of the doses was eliminated in the feces. Radioactivity was secreted in milk, but these residues were in all cases very low. Radioactive residue occurred in tissues as well but at low levels, in decreasing order as follows: omental fat > liver subcutaneous fat > kidney > brain > heart > biceps femoris > longissimus dorsi. The residue stored in fat was identified as carbofuran. The liver contained hydroxy carbofuran and one unidentified metabolite but no carbofuran. The other tissues contained only phenolic metabolites. This study indicates that proper carbofuran use in rice in the Philippines will present minimal risks to goats that consume treated crops residues, or to humans who consume meat or milk from exposed animals.

Source or Periodical Title

PHILIPP. AGRIC.

Page

149-155

Document Type

Article

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