Further evidence for entry of infectious bovine rhinotracheitis virus into bovine kidney cells

Abstract

The penetration of bovine kidney cells by infectious bovine rhinotracheitis virus, a member of the herpesvirus group, was investigated using the direct immunoferritin labeling technique. Electron microscopic examination of infected cells after 10 min at 37°C revealed fusion between viral envelope and cell membrane; the former reacted with the ferritin particles conjugated with antiviral antibody. However, shortly after penetration of the nucleocapsid, viral-specific antigenic sites on the plasma membrane were not detected by the immunoferritin technique. Antigenically reactive structures in a disorganized array were frequently detected extracellularly, situated above the penetration sites as indicated by the internalized nucleocapsids. © 1978 Springer-Verlag New York Inc.

Source or Periodical Title

Current Microbiology

ISSN

3438651

Page

145-150

Document Type

Article

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