Effect of vitamin c and probiotics on broilers performance and claudin-2 (CLDN-2) expression under heat stress

Issue Date

6-2023

Abstract

This study was conducted to investigate the effect of vitamin C and probiotic which consists of five species of beneficial bacteria and two species of fungi on performance, blood parameters, and intestinal CLDN-2 gene expression of broilers during heat stress (HS). A total of 400 broilers were randomly divided into five groups, each of which received a different treatment. The first group was considered a negative control and did not experience any HS (C-); the second group was considered a positive control (C+) and was exposed to HS; the third group received only vitamin C (250 mg/L in drinking water); the fourth group received only the recommended dose of probiotics; and the fifth group received a combination of both vitamin C and probiotics (250 mg/L in drinking water and recommended dose, respectively). The broiler’s performance, blood parameters, and intestinal CLDN-2 gene expression were assessed. The results showed that the administration of probiotics and vitamin C increased the broiler's feed intake and decreased the feed conversion ratio (p < 0.05). Heat stress increased the broiler's blood total protein, glucose, cholesterol, triglyceride, and liver enzyme concentration (p < 0.05). While the supplementation of vitamin C and probiotics decreased these parameters during HS (p < 0.05). Vitamin C administration reduced the intestinal CLDN-2 gene expression in broilers, during HS (p < 0.05). Heat stress negatively affected the broiler's performance and increased the mortality rate and intestinal CLDN-2 gene expression, whereas, the supplementation of vitamin C decreased the deleterious effect of HS in broilers.

Source or Periodical Title

Philippine Agricultural Scientist, The (Formerly: The Philippine Agriculturist)

ISSN

0031-7454

Volume

106

Issue

2

Page

223-237

Document Type

Article

College

College of Agriculture and Food Science (CAFS)

Frequency

quarterly

Physical Description

graphs, tables, bibliography

Language

English

En – AGROVOC descriptors

ASCORBIC ACID; PROBIOTIC; BROILER CHICKENS; HEAT EXHAUSTION; EPITHELIUM; FEED INTAKE; GENE EXPRESSION; GROWTH RATE

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