Molecular characterization of lumpy skin disease virus emerged in Northern Vietnam in 2020 based on RPO30 and GPCR genes

Issue Date

7-2022

Abstract

Lumpy skin disease (LSD) is a devastating viral disease of cattle causing economic losses in the cattle industry. LSD was first reported in Vietnam in 2020, therefore, there have not been many studies focused on the detection of LSD virus (LSDV) or the molecular characterization of the virus. In this study, two suspected LSD cattle displaying clinical signs were investigated and the presence of the LSDV genes was confirmed. In addition, the molecular characterization of obtained Vietnamese isolates based on analyzing the RPO30 and GPCR genes was performed. Phylogenetic analysis of the full-length RPO30 and GPCR sequences revealed that the current Vietnamese LSDVs clustered closely with five previously reported Vietnamese and Chinese strains. Furthermore, LSDVs differ from the reported LSDV field isolates in Africa, the Middle East, and Europe. According to deduced amino acid (aa) sequence comparison, some aa substitutions were observed in the RPO30 and GPCR protein of obtained LSDVs. Interestingly, two aa substitutions S98F and L103F were firstly found in the RPO30 of one Vietnamese strain in this study.

Source or Periodical Title

Philippine Journal of Veterinary Medicine

ISSN

0031-7705

Volume

59

Issue

2

Page

155-163

Document Type

Article

Frequency

semi-annually

Physical Description

illustrations; tables; map

Language

English

En – AGROVOC descriptors

CATTLE; LUMPY SKIN DISEASE; LUMPY SKIN DISEASE VIRUS; VIROSES; PLANT VIRUSES; MOLECULAR CHARACTERIZATION; VIET NAM

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