Anti-Mycobacterium phlei activity of the bark of Ziziphus talanai (Blanco) Merrill

Issue Date

12-2009

Abstract

The bark of Ziziphus talanai (Blanco) Merrill, a tree endemic to the Philippines, is traditionally used in Antique to cure kidney problems such as urinary tract infections (UTI), and skin diseases such as scabies and ringworm. Its antimicrobial activity was screened against several microorganisms to have a more comprehensive anti-infective profile of the plant. The MeOH extract of Z. talanai bark exhibited antimicrobial activity against Gram-positive Mycobacterium phlei, S. aureus and B. subtilis at 20,000 μg and 2,000 μg but was inactive against Gram-negative E. coli, P. aeruginosa, C. albicans and S. cerevisiae. It has minimal antifungal activity against T. mentagrophytes. The MeOH extract of Z. talanai is therefore inactive against uncomplicated UTI, which is mostly caused by E. coli. Further bioassay- guided isolation and subsequent spectral analysis yielded ceanothic acid, whose activity is specific to M. phlei at 100 μg. M. phlei causes chronic ambulatory peritoneal dialysis- associated peritonitis.

Source or Periodical Title

Philippine Agricultural Scientist, The (Formerly: The Philippine Agriculturist)

ISSN

0031-7454

Volume

92

Issue

4

Page

388-391

Document Type

Article

College

College of Agriculture and Food Science (CAFS)

Frequency

quarterly

Physical Description

illustrations; tables; references

Language

English

Subject

antimicrobial activity, ceanothic acid, peritonitis, Mycobacterium phlei, Ziziphus talanai

En – AGROVOC descriptors

ZIZIPHUS; MYCOBACTERIUM; BARK EXTRACTS; ANTIMICROBIAL PROPERTIES; MEDICINAL PLANTS

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