Issue Date
2024
Abstract
Primary dysmenorrhea, a common menstrual pain, is often treated with nonsteroidal anti- inflammatory drugs (NSAIDs), which may cause side effects. In contrast, herbal medicine, such as Mimosa pudica L., has been used in the Philippines due to its accessibility and reportedly fewer side effects. This study investigated the analgesic potential of an aqueous M. pudica leaf decoction in a primary dysmenorrhea mouse model. Phytochemical analysis of the extract was also conducted and results revealed the presence of alkaloids, flavonoids, saponins, tannins, sterols, triterpenoids, and glycosides. Twenty sexually mature female ICR mice (Mus musculus) were orally pretreated with estradiol valerate for four days, then treated on the fifth day with one of the following through gavage method: 10 mLK-1 distilled water (negative control), aqueous M. pudica leaf decoction (100, 200, and 400 mgK-1), and 90 mgK-1 mefenamic acid (positive control). Thirty minutes later, each mouse received intraperitoneally 0.4 IU oxytocin to induce abdominal writhing. Writhing frequency was highest and lowest in the negative and positive control groups, respectively, and intermediate in animals treated with 100 and 200 mgK-1 extract. No significant difference, however, was found among groups in terms of writhing responses, as well as uterine morphometry. Uterine histological analysis among treatment groups showed normal tissue organization. Given the presence of compounds with known analgesic properties in the extract, a higher concentration may produce a strong analgesic activity. Further studies may support the use of M. pudica as an alternative treatment against primary dysmenorrhea.
Source or Periodical Title
UP Los Baños Journal
Volume
22
Issue
3
Page
73-88
Document Type
Article
College
College of Arts and Sciences (CAS)
Recommended Citation
De Guzman, Paula Bianca D. and Maligalig, Maria Dalisay G., "Analgesic potential of the Mimosa pudica L. leaf decoction using the primary dysmenorrhea mouse model" (2024). Journal Article. 6312.
https://www.ukdr.uplb.edu.ph/journal-articles/6312