Modeling long ncRNA-mediated regulation in the mammalian cell cycle

Abstract

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that are not translated into proteins. They have recently gained widespread attention due to the finding that tens of thousands of lncRNAs reside in the human genome, and due to an increasing number of lncRNAs that are found to be associated with disease. Some lncRNAs, including disease-associated ones, play different roles in regulating the cell cycle. Mathematical models of the cell cycle have been useful in better understanding this biological system, such as how it could be robust to some perturbations and how the cell cycle checkpoints could act as a switch. Here, we discuss mathematical modeling techniques for studying lncRNA regulation of the mammalian cell cycle. We present examples on how modeling via network analysis and differential equations can provide novel predictions toward understanding cell cycle regulation in response to perturbations such as DNA damage.

Source or Periodical Title

Methods in Molecular Biology

ISSN

10643745

Page

427-445

Document Type

Article

Subject

Cell cycle, DNA damage, lncRNA, Mathematical model, Networks, Regulation

This document is currently not available here.

Share

COinS