Reduction in clinicopathological lesions in canine mange with various kakawate (Gliricidia sepium) preparations

Professorial Chair Lecture

Southern California Filipino Veterinary Medical Association Professorial Chair Lecture

Place

College of Veterinary Medicine, UPLB, College, Laguna

Date

6-30-2004

Abstract

Twenty five (25) mixed breed dogs of either sex infested with sarcoptic mange were used in the experiment and a total of eighteen dogs were used for the experiment involving demodecosis. Two treatment groups and one control groups was used in the experiment. The first treatment group consisted of animals, which were treated with a soap preparation with kakawate extract. The second treatment group consisted of dogs which were treated with the kakawate decoction preparation. The control group were those subject animals which were bathed using a soap without the kakawate extract. To test the significance between the treatment means, Analysis of Variance (ANOVA) and pair wise mean comparison using Duncan's Multiple Range Test (DMRT) were performed. For the dogs with sarcoptic mange, ten animals were placed under treatment groups 1 and 2 and five animals under the control group. For the dogs with demodecosis, the treatment 1 and 2 had six animals each. The control group also had six dogs under this category. The dogs were bathed using their respective decoction or soap once a week for six weeks. A macroscopic dermatologic evaluation was performed using a visual dermatologic scoring on the gross lesions based on their presence and number. A microscopic dermatologic evaluation was performed on skin biopsies using a scoring of the lesions based on the number present. Percentage reduction of mites was obtained from the skin scrapings of the sample animals.

After the 6-week experimental period, the experiment involving scabies showed there was a significant difference in the mean % reduction of mites between the two treatment groups from the control group. There was no significant difference in the reduction of mites between the two treatment groups. There was a significant reduction of lesions between the two treatment groups and the control group. The difference in the reduction of macroscopic lesions between the two treatment groups was not statistically significant. Results also showed that there was no significant difference in the mean % reduction of mites between the treatments from the control group. The reduction of mites between the treatment groups was not significant. There was a significant reduction of macroscopic lesions between the decoction treatment group and the control group. The difference in the reduction of macroscopic lesions between the two treatment groups was also statistically significant. There was no significant difference in the reduction of microscopic lesions between the treatment groups but a significant difference was observed between the treatment and the control groups.

Location

UPLB Main Library Special Collections Section (USCS)

College

College of Veterinary Medicine (CVM)

Language

English

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