A cytogenetic study on the effects of farm chemicals on human leukocytes in vivo.

Date

3-1984

Degree

Bachelor of Science in Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Celia B. Dela Viña

Abstract

The possible effect of exposure to farm chemicals on the frequency of chromosomal aberrations in four male laborers was investigated. This study was conducted to (1) determine and assess the possible effects of farm chemicals in human leukocytes in vivo; (2) identify and characterize chromosomal aberrations using gross morphology and karyo-type analyses; (3) find and evaluate possible relation-ship(s) of the number and type of aberrations on the length of exposure to farm chemicals (in years), ages and on the degree of smoking and alcohol drinking, Chromosomal abnormalities were observed. These were chromosome and chromatid types of gaps and creaks, loose pairing, minimally and maximally condensed chromosomes and elongated chromosomes. These structural anomalies of the chromosome, however, were found to be not statistically significant before and during peak of exposure to farm chemicals. Moreover, the chromosome type of aberration in general did not differ from the chromatid type of aberration in both treatments. The mitotic index did not differ significantly between the two treatments also. Due to an inadequate number of subjects used, age, length of exposure, smoking and alcohol drinking were not correlated to the number and type of aberrations observed. The findings revealed in this study no cytogenetic effect of farm chemical-exposure on the chromosomes of the affected individuals.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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