"Cytogenetic effects of chichirica (Catharanthus roseus - L.) crude leaf extract on human leukocytes cultured in vitro"

Date

3-1997

Degree

Bachelor of Science in Biology

Major Course

Major in Cell Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Merlyn S. Mendioro

Abstract

A study was conducted to test whether Chichinca(Catharanthus roseus L ) crude leaf extract could induce cytological aberrations on human leukocytes cultured in vitro One percent, 3% and 5% weight by volume extract from Chichinca leaves were obtained and treated to cultured cells incubated at 37°C for 48 hours The cultured cells were exposed to the treatment for another 24 hours before harvested and cytologically observed Statistical analysis using repeated measure design and DMRT for tests with significant differences at 5% significance level were done The treatment could significantly reduce the number of dividing cells. Mitotic index decreased from 0.144% to 0.074%. An increase the number of cells with highly condensed chromosome configuration was observed(from 0 09% to 0.45%). The treatment did not significantly show differences to the tests on chromosomal gaps, breaks and premature separation of sister chromatids

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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