Effects of nami (Dioscorea hispida Dennst.) on prenatal laboratory rats

Date

3-1991

Degree

Bachelor of Science in Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Pablo P. Ocampo

Abstract

Pregnant laboratory rats were treated with chloroform extract of D hispida on day 6-15v of gestation. The dams were sacrificed on day 21 of gestation. Dams treated with 55 mg/kg (high dose) exhibited 30.43% mortality and low pregnancy rate of 47.83% than the low dose group and control, indicating that D. hispida is maternally toxic. Body weight gain during pregnancy of the high dose treated dams were found higher than the other test group, but no significant variations were detected. No significant effect on the various reproductive parameters, viz: number of corpus luteum, number of implantation sites, number of resorbed fetus, fetal weight and litter size were observed. Slight embryotoxicity was suggested by the high number of resorbed fetus, fetal weight and low implantation sites in the high dose level compared to the low dose and control groups. Soft tissue analysis showed no apparent malformation in all test groups. Skeletal analysis revealed signs of malformations in the low and high dose group. Some of the irregularities

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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