Histopathological analysis of the effects of achuete (Bixa orellana L.) aqueous extract on selected organs (liver, kidney and testis) of sexually mature male albino rats (Rattus norvegicus)

Date

5-1994

Degree

Bachelor of Science in Biology

Major Course

Major in Cell Biology

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Merlyn S. Mendioro

Abstract

Various concentrations (0%, 25%, 50% and 75%, of aqueous achuete (Bixa crellana, seed extract were evaluated for effects on body and organ weights and organ physiology of 20 mature male albino rats. The extract was orally administered to the animals by gavage technique at a ratio of 1 m1/100 g bw once a day for 30 consecutive days. Upon termination of treatment, the liver, kidneys and testes were incised and analyzed for morphological and histological changes. Results showed that body, liver, and testis weights of rats treated with different levels of the extract were not significantly different. However, kidney weights were statistically significant. The weight of kidney decreased as the concentration of the seed extract increased. Slight to moderate congestion of major blood vesicle was observed for all treatments except the control. Swelling of hepatic cord was further noted for rats given the 50% and 75% concentration. Kidney showed slight congestion of tubular cells for rats given the extract, with a clear staining substance present under the 50% and 75% treatment levels. The testes were apparently unaffected and showed no change. As the concentration was increased, there was a corresponding increase in effect on the organs of the subject.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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