Isolation and partial characterization of cytotoxic constituents with antimicrobial activity from Blumea balsamifera (Linn.) DC.

Date

10-2000

Degree

Bachelor of Science in Chemistry

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Evamarie P Capareda

Abstract

Dried ground leaves of Blumea balsamifera were extracted with solvents of different polarity: petroleum ether, CI-12C12, 1:1 (v/v) CHC13:CH3OH, CH3OH and then H2O. The cytotoxic activity of the extracts were tested against Anemia sauna (brine shrimp). Three isolates were obtained from a series of modified flash column chromatography of the petroleum ether extract. The isolates, at 1000 ppm concentration, were also found to have antimicrobial activity against E. colt, S. aureus and C albicans. Based on the IR, NMR, and UV analyses, isolate S-HI is probably a derivative of anthracene, isolate S-I2 has a hydroxyl group, and a triply bonded carbon, either an alkyne or a nark, as functional groups, and isolate S-I4 has both a ketone and a carboxylic acid. Both S-I2 and S-I4 are probably sesquiterpenes.

Language

Filipino

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

This document is currently not available here.

Share

COinS