Effects of a commercial food supplement on the tryglyceride, serum total cholesterol and fasting blood sugar levels in matured male Sprague Dawley rats

Date

4-2009

Degree

Bachelor of Science in Chemistry

College

College of Arts and Sciences (CAS)

Adviser/Committee Chair

Nieva T. Librojo-Basilio

Abstract

RIVADENEIRA, JOEL PADILLA, College of Arts and Sciences, University of the Philippines Los Banos. March 2009. EFFECTS OF A COMMERCIAL FOOD SUPPLEMENT ON THE TRIGLYCERIDE, SERUM TOTAL CHOLESTEROL, AND FASTING BLOOD SUGAR LEVELS IN MATURED MALE SPRAGUE DAWLEY RATS.

Adviser: Dr. Nieva T. Librojo-Basilio

The effects of a commercial food supplement on the triglyceride, serum total cholesterol, and fasting blood sugar on matured male Sprague Dawley rats were studied. Sixteen matured male Sprague Dawley rats aged sixteen months were randomly grouped into four (I, II, III, IV) and placed in separate cages. These rats were fed with the food supplement for fourteen days and then sacrificed. Group I served as the control group, groups II to IV were given 0.0442 g, 0.0884 g, and 0.1768 g of food supplement respectively. Weights of each rat were determined at day 0, 8, and 15.

Statistical analysis using One-Way Analysis of Variance (ANOVA) procedures of serum triglyceride concentration showed no significant difference between the levels of treatment.. However for the scrum total cholesterol, there was a statistically significant difference between the levels of treaunent_ Comparison of means using the least square difference (LSD) method showed that the control group is significantly different to groups II, Ill, and IV in terms of total cholesterol concentration. However, concentrations of serum total cholesterol among treated groups are not significantly different. For the serum fasting blood sugar concentration, there was no significant difference between the levels of treatment.

Linear regression analysis conducted using Pearson's Correlation showed that there was a significant positive linear correlation between the levels of triglycerides, total cholesterol, and fasting blood sugar.

It is recommended that same study be done using a different time line. Instead of two weeks of food supplement administration, we could lengthen the time span. Also, we could use a relatively younger rats sample so as to prevent them from dying due to ageing during the experiment.

Language

English

Location

UPLB Main Library Special Collections Section (USCS)

Call Number

Thesis

Document Type

Thesis

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