Time course study on the effect of honey and propolis treatment on the neurologic deficit, infarct and neural damage in the celebral cortex hippocampus in ischemia-induced stroke rats

Date

6-2015

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Maria Amelita C. Estacio

Co-adviser

Therese Marie A. Collantes

Abstract

The time course effect of honey and propolis treatment on the neurologic deficit, brain infarction and lesions in surgically-induced ischemic stroke was investigated using 47 adult male Sprague-Dawley rats that were randomly divided into distilled water, honey and propolis treated groups. Neurologic deficit scoring, brain infarct assessment with 2,3,5-triphenyl tetrazolium choride staining and hippocampal, and cerebrocortical damage evaluation with H&E staining was done at specific time periods. Honey and propolis treatment attenuated the neurologic motor deficits, hippocampal fibrosis and gliosis and cerebrocortical edema, fibrosis and red neuron proliferation. Moreover, brain infarct size was reduced and hippocampal symmetry was also restored. These results suggest that honey and propolis from the Philippine stingless bees possessed neuroprotective activity to minimize the motor impairments, neural damage, and ischemic insult leading to brain infarct formation as well as restore the normal symmetry of the hippocampus caused by ischemic stroke.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Call Number

LG 993.5 2015 V4 A73

Document Type

Thesis

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