Date

2021

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Marco F. Reyes, Michelle Grace V. Paraso

Abstract

The wound healing properties of saltwater crocodile blood (Crocodylus porosus) plasma was assessed by topical administration on skin incision wounds of male ICR mice. Thirty male ICR mice were divided among three treatments namely 0.9% NSS, povidone-iodine solution, and saltwater crocodile blood plasma. Macroscopic and microscopic changes on the wound were evaluated on days 7, 14, and 21. Hyperemia and wound elevation were observed on all treatments and plasma group showed that hyperemia and wound elevation resolved faster when treated with saltwater crocodile blood plasma compared to povidone-iodine. Wounds treated with plasma had smaller scabs compared with povidone-iodine and scar formation was absent for wounds treated with plasma on day 21 compared to NSS and povidone-iodine where slight scar formation was observed. For microscopic changes, povidone-iodine treatment showed thicker epidermis and wider wound gap as compared to plasma treatment while no significant difference was observed between NSS and plasma treatment. However, more neutrophils were observed in plasma treatment compared to NSS treatment. Saltwater crocodile blood plasma showed some evidence of beneficial properties in wound healing of skin incision wounds in male ICR mice making it a candidate as a future alternative for wound therapeutics.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Best Thesis in Veterinary Surgery, 2021

Document Type

Thesis

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