Healing activity of propolis-alginate dressing from the Philippine stingless bees (Tetragonula biroi Friese) in a mouse model of excisional wound

Date

6-2016

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Maria Amelita C. Estacio

Co-adviser

Mary Jasmin C. Ang

Abstract

Wound healing activity of propolis-alginate dressing on 5 mm x 5 mm full thickness excisional wounds was investigated using thirty six-week old male mice randomly divided into three treatment groups (n=10/group): Group 1, povidone iodine patch Group 2, deproteinized calf blood extract and Group 3, propolis-alginate dressing. Total wound score was evaluated daily for 21 days using six parameters: wound edges, erythema, exudates, pus, necrotic tissue and scabs. Mean duration of healing and percent wound contraction were computed. Skin samples of mice from treatment groups were obtained for histopathologic description. Propolis-alginate treatment significantly enhanced the rate of excisional wound healing in terms of low MTWS, fast wound contraction and short duration of healing. Histopathologic evaluation revealed complete re-epithelialization with hair follicles and sebaceous glands formation, normal dermal thickness, mild epidermal thickening and absence of scarring with propolis-alginate treatment. Propolis-alginate treatment was the cost effective with savings of 260.92 Php for the treatment duration. These results show the effectiveness of propolis-alginate dressing in excisional wound management in mice.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Call Number

LG 993.5 2016 V4 R34

Document Type

Thesis

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