Healing activity of propolis-alginate dressing from the Philippine stingless bees (Tetragonula biroi Friese) in a mouse model of excisional wound
Date
6-2016
Degree
Doctor of Veterinary Medicine
College
College of Veterinary Medicine (CVM)
Adviser/Committee Chair
Maria Amelita C. Estacio
Co-adviser
Mary Jasmin C. Ang
Abstract
Wound healing activity of propolis-alginate dressing on 5 mm x 5 mm full thickness excisional wounds was investigated using thirty six-week old male mice randomly divided into three treatment groups (n=10/group): Group 1, povidone iodine patch Group 2, deproteinized calf blood extract and Group 3, propolis-alginate dressing. Total wound score was evaluated daily for 21 days using six parameters: wound edges, erythema, exudates, pus, necrotic tissue and scabs. Mean duration of healing and percent wound contraction were computed. Skin samples of mice from treatment groups were obtained for histopathologic description. Propolis-alginate treatment significantly enhanced the rate of excisional wound healing in terms of low MTWS, fast wound contraction and short duration of healing. Histopathologic evaluation revealed complete re-epithelialization with hair follicles and sebaceous glands formation, normal dermal thickness, mild epidermal thickening and absence of scarring with propolis-alginate treatment. Propolis-alginate treatment was the cost effective with savings of 260.92 Php for the treatment duration. These results show the effectiveness of propolis-alginate dressing in excisional wound management in mice.
Language
English
Location
UPLB College of Veterinary Medicine (CVM)
Call Number
LG 993.5 2016 V4 R34
Recommended Citation
Rada, Stephani Marie A., "Healing activity of propolis-alginate dressing from the Philippine stingless bees (Tetragonula biroi Friese) in a mouse model of excisional wound" (2016). Undergraduate Theses. 4642.
https://www.ukdr.uplb.edu.ph/etd-undergrad/4642
Document Type
Thesis