Cicatrizing effects of oregano (Oreganum vulgare) crude leaf extract on experimentally induced epidermal burns in rabbits (Oryctolagus cuniculus)

Date

6-2016

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Marco F. Reyes

Co-adviser

Rey b. Oronan

Abstract

total of 10 apparently healthy, adult rabbits, were used in this study. Five (5) round, epidermal burn wounds were induced on the animal?s dorsum and randomly assigned into five treatment groups: A (negative control: no treatment), B (Oreganum vulgare poultice), C (pure petrolatum), D (Oregano petrolatum) and E (Silver Sulfadiazine) to evaluate the cicatrizing effects of oregano (Origanum vulgare L.) crude leaf extract on burns. The treatments were administered once daily for the duration of the study and the macroscopic and histopathological characterization and photodocumentation of the burn wounds were done on days seven, 14, and 21 post-induction. Moderate hyperemia was observed in all treatment groups for the first seven days and complete cicatrization on day 21. Presence of scab formation (p=0.0051), wound elevation (p=0.0.0348) and inflammation (p=0.0.0379) are significantly different between treatment groups on day 7 (p=0.05). Oregano petrolatum showed better wound contraction as compared to pure petrolatum. Oregano as an alternative treatment to epidermal burn wounds is comparable with that of the commercially available treatment.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Call Number

LG 993.5 2016 V4 D43

Document Type

Thesis

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