Ultrasonographic features of experimentally induced corneal ulcer healing using autologous serum in dog (Canis familiaris)

Date

6-2016

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Adviser/Committee Chair

Jezie A. Acorda

Abstract

Fifteen adult, female, non-descript dogs were used to determine the ultrasonographic features of experimentally induced corneal ulcer healing given normal saline solution (Group A), tobramycin (Group B) and autologous serum (Group C) at day seven (7), 14 and 21.An ultrasound machine equipped with a 7.5 MHz linear array scanner with an aid of a modified stand-off pad was utilized in this study. Upon ultrasound examination, the cornea (hyperechoic), anterior chamber (anechoic), lens (anechoic), vitreal chamber (anechoic) and the retina with other choroidal layers (mesh of hyperechoic and hypoechoic structures) were successfully visualized. Corneal ulceration appeared as hypoechoic with hyperechoic structures. The mean measurement for the central corneal thickness was 589.87 ± 0.2517 μm. Groups B and C had significantly greater decrease in corneal ulcer depth and gap at day 21 than Group A. Echo mean analysis revealed increasing echogenicity as the healing process progressed throughout the observation period and could be attributed to fibroblastic proliferation. The results suggest that ultrasound can be used to monitor and evaluate the healing process and autologous serum is as effective in treating corneal ulcers as tobramycin.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Call Number

LG 993.5 2016 V4 C36

Document Type

Thesis

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