Acute Oral Toxicity Test of the Philippine Indigenous Berry Lipote (Syzygium polycephaloides (C. B. Rob.) Merr.): Assessment of Physiological, Hematological, and Biochemical Safety Profiles in Mice

Date

2022

Degree

Doctor of Veterinary Medicine

College

College of Veterinary Medicine (CVM)

Abstract

An acute oral toxicity test was conducted to investigate the toxic effects of lipote (Syzygium polycephaloides (C. B. Rob.) Merr.) berry in male and female ICR mice at doses of 55, 175, 550, 2000, and 5000 mg/kg BW. At the end of the 14-day experimentation period, no physical, behavioral, neurologic, or cardiorespiratory signs of toxicity nor mortalities were recorded throughout the study. Physiologic parameters such as body weight, body weight gain, feed and water intake registered normal in LFE-treated mice. Hematologic values such as total RBC, total WBC, and differential WBC counts for both sexes remained normal, apart from the male mouse administered the 2000 mg/kg dose LFE which presented with erythrocytopenia, leukocytopenia, and lymphocytopenia after the end of the experimentation period, most likely due to extraneous factors unrelated to treatment. Blood creatinine and blood urea nitrogen values remained within their respective normal reference ranges. Generally, the results of this acute oral toxicity study are comparable to that of similar studies done on related Syzygium species. The presented findings suggest that lipote fruit extract is non-toxic, has an LD50 above 5000 mg/kg, and like other closely related Syzygium berries, has no adverse effects on the physiologic, hematologic, and kidney health parameters of ICR mice. Sub-chronic and chronic toxicity studies must be conducted to determine the safety of continuous oral ingestion of lipote fruit.

Language

English

Location

UPLB College of Veterinary Medicine (CVM)

Notes

Award: Award for Best Undergraduate Thesis in Veterinary Pathology

Document Type

Thesis

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