Rice bran phospholipid-based nanovesicles for enhanced oral and topical delivery of capsaicinoids

Creator

Anabel B. Abulencia, University of the Philippines Los Banos
Mark Louis P. Vidallon, University of the Philippines Los Banos
Ronaniel A. Almeda, University of the Philippines Los Banos
Kevin C. Salamanez, University of the Philippines Los Banos
Evelyn B. Rodriguez, University of the Philippines Los Banos

Issue Date

12-2020

Abstract

The current work aimed to fabricate a rice bran phospholipid-based nanovesicular system for oral and topical delivery of capsaicinoids from Capsicum annuum. Using a modified thin film-hydration method, capsaicinoid-loaded nanovesicles (CLNVs) with encapsulation efficiency of 92.31 ± 5.35% and a mean diameter of 134 ± 2 nm, were produced. Based on in vitro release studies, the produced CLNVs exhibited a slow and limited release in both simulated salivary and gastric fluids, and selective release in simulated intestinal fluid, suggesting the opportunity for targeting release via the gastro-intestinal tract during oral delivery. Furthermore, the observed limited release of capsaicinoids in surfactant solution is a desirable property for topical delivery formulations. The fabricated delivery vehicle has also shown a masked and reduced irritation effect that co-occur with the strong anti-inflammatory activity of the capsaicinoids. Using a modified duck egg chorioallantoic membrane (CAM) assays, it was demonstrated that encapsulation into nanovesicles was able to reduce the irritancy of capsaicinoids by almost 50% and, at the same time, improve the anti-inflammatory activity by up to 10 folds. These results demonstrated the potential of CLNVs to be developed as oral and topical delivery systems for capsaicinoids.

Source or Periodical Title

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

Volume

60

Page

1-9.

Document Type

Article

Physical Description

illustration; diagram; graphs; table; references

Language

English

Subject

Anti-inflammatory, Capsaicinoids, Chorioallantoic membrane assay, Controlled release, Nanoencapsulation, Rice bran phospholipids

Recommended Citation

Abulencia, A.B., Vidallon, M.L.P., Almeda, R.A., Salamanez, K.C., Rodriguez, E.B. (2020). Rice Bran Phospholipid-Based Nanovesicles for Enhanced Oral and Topical Delivery of Capsaicinoids. Journal of Drug Delivery Science and Technology, 60, 1-9. 10.1016/j.jddst.2020.102005.

Identifier

DOI:10.1016/j.jddst.2020.102005

Digital Copy

yes

En – AGROVOC descriptors

ANTI-INNFLAMMATORY; CAPSAICINOIDS; CHORIALLANTOIC MEMBRANE ASSAY; CONTROLLED RELEASE; NANOENCAPSULATION; RICE BRAN