Hypoglycemic effect of Lagerstroemia speciosa (L.) Pers. on alloxan-induced diabetic mice
Issue Date
12-2009
Abstract
Lagerstroemia speciosa (L.) Pers. known as "banaba" is traditionally used as a herbal medicine in the Philippines. Although Lagerstroemia speciosa has been shown to produce hypoglycemic effects in some mice models of diabetes, there are no reports of the effects of this substance in alloxan-induced diabetic mice. Thus, the present study aimed to elucidate the hypoglycemic effects of L. speciosa in ICR strain of mice. Diabetes was induced by the intraperitoneal injection of alloxan. Spray dried L. speciosa powder (1000 mg/kg) or decoction (20 ml/kg) was administered on alloxan-induced diabetic male ICR mice for 28 days by gavage. The effects of L. speciosa on blood and urinary glucose levels and body weight, feed intake and water intake were measured. Spray dried L. speciosa powder and decoction significantly reduced blood (P < 0.01) and urinary glucose (P < 0.05) levels of diabetic mice from day 8 to 28 compared with the diabetic control. These mice also had lower (P < 0.05) body weight compared with the diabetic control from day 15 to day 28. The feed intake of diabetic mice was higher (P < 0.05) compared with non-diabetic control and L. speciosa-treated diabetic mice from day 22 to 28. A comparable fluid intake was evident among non-diabetic mice and L. speciosa-treated diabetic mice from day 8 to 28 which was significantly lower (P < 0.01) compared with the diabetic mice. These results suggest that L. speciosa possesses beneficial antihyperglycemic activity in controlling the elevated glucose level in alloxan-induced diabetic mice. © 2009 Academic Journals.
Source or Periodical Title
Journal of Medicinal Plants Research
ISSN
1996-0875
Volume
3
Issue
12
Page
1066-1071
Document Type
Article
Physical Description
graphs
Language
English
Subject
Alloxan-induced diabetes, Antihyperglycemic activity, Diabetes mellitus, Lagerstroemia speciosa, Mice
Recommended Citation
Tanquilut, N.C., Tanquilut, M.R.C., Estacio, M.A.C., Torres, E.B., Rosario, J.C., Reyes, B.A.S. (2009). Hypoglycemic effect of Lagerstroemia speciosa (L.) Pers. on alloxan-induced diabetic mice. J Med Plant Res. 3 (12), 1066-1071.
Digital Copy
yes