Efficacy, mutagenicity and toxicity of trichosetin as a new antibiotic for poultry

Issue Date

6-2007

Abstract

Trichosetin is a new antibiotic produced from the dual culture of Catharanthus roseus callus and Trichoderma harzianum. Experiments were conducted to determine its efficacy and safety as a therapeutic agent for poultry. Antimicrobial assay showed that this antibiotic was inhibitory to a multidrug-resistant strain of Staphylococcus sp. It also exhibited moderate activity against Pasteurella multocida. Toxicity assay showed that it was not toxic to chicken when administered orally at 50 mg kg-1 body weight daily for 1 wk. Mutagenicity assay revealed that it was not mutagenic. These results suggest that trichosetin can be developed as a therapeutic agent for poultry.

Source or Periodical Title

Philippine Agricultural Scientist

ISSN

317454

Volume

90

Issue

2

Page

91-95

Document Type

Article

Language

English

Subject

Antibiotic, Mutagenicity, Poultry, Toxicity, Trichosetin

Digital Copy

none

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