Repeated oral dose of monocrotophos in Goats: Its bioaccumulation

Abstract

Monocrotophos bioaccumulation in goats was studied through repeated oral doses followed by serial slaughter of the animals. Twelve yearling local male goats were fed daily with 120 g commercial concentrate (17% CP), napier grass ad libitum, and were orally treated daily with 0.006 mg/kg body weight of 14C monocrotophos. The animals were randomly selected for slaughter on days 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, and 36 of the dosing period. Urine and feces were collected separately for the measurement of monocrotophos elimination. The liver, biceps femoris, longissimus dorsi, and abdominal fat were also collected for monocrotophos residue analysis through radioactive measurement. The highest rate of accumulation of the pesticide was in the liver (0.063 ppm), followed by blood (0.049 μg/ml), longissimus dorsi (0.047 ppm), biceps femoris (0.024 ppm), and abdominal fat (0.017 ppm). Based on the two-compartment model using non-linear regression analysis, the highest rate constant of monocrotophos uptake was found in the liver (0.02383 ± 0.00485 μg/g tissue/ day), followed by longissimus dorsi (0.02356 ± 0.00266 μg/g tissue/day), biceps femoris (0.00784 ± 0.00211 μg/g tissue/day), and abdominal fat (0.00416 ± 0.00074 μg/g tissue/day). The trend of monocrotophos bioaccumulation in tissues followed non-linear regression: Q(t) = 0.027 (e0.00025 t -e-0.17474 t), (R2 = 0.67); Q(t) = 0.057 (e-0.0066 t -e-0.25665 t), (R2 = 0.86); Q(t) = 0.017 (e0.0069 t -e-0.1358 t), (R2 = 0.93); and Q(t) = 0.055 (e0.00995 t -e-2523 t), (R2 = 0.88), for biceps femoris, longissimus dorsi, abdominal fat, and liver, respectively.

Source or Periodical Title

Philippine Agricultural Scientist

ISSN

317454

Page

13-20

Document Type

Article

Subject

Bioaccumulation, Goat, Monocrotophos, Tissues

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