Bioprospecting of Turbinaria ornate (Fucales, Phaeophyceae) for cosmetic application: antioxidant, tyrosinase inhibition and antibacterial activities

Issue Date

12-2020

Abstract

Brown macroalgae are rich sources of polyphenols with diverse pharmacological activities relevant to formulation of novel cosmetic products. This study evaluated the antioxidant, tyrosinase inhibition, and antibacterial properties of a brown macroalga, Turbinaria ornata (Turner) J. Agardh. The seaweed extract had a total phenolic content of 18.50 ± 0.17 mg GAE/g. Antioxidant efficiency of T. ornata exerted high copper reduction antioxidant capacity and potent DPPH radical scavenging activity in a dose-dependent manner with EC50 value of 24.34 μg GAE/mL and 22.10 μg GAE/mL, respectively showing its potential as an alternative source of effective natural antioxidant. T. ornata has an excellent tyrosinase inhibitory activity (EC50 of 67.50 μg GAE/mL), more effective than that of commercially available skin-lightening ingredient, kojic acid with EC50 of 109.8 μg/mL. In vitro antibacterial activity using microdilution technique assay demonstrated T. ornata possessed strong inhibitory activity against common bacterial skin pathogen such as Staphylococcus aureus (MIC = 125 μg/mL), Staphylococcus saprophyticus (MIC = 125 μg/mL), Staphylococcus epidermidis (MIC = 250 μg/mL) and Serratia marcescens (MIC = 500 μg/mL). The current study is the first report in the Philippines exploring the biological properties of T. ornata as potential alternative source of skin lightening active ingredient important for cosmetic application.

Source or Periodical Title

Journal of the International Society for Southeast Asian Agricultural Sciences (Journal of ISSAAS)

ISSN

0859-3132

Volume

26

Issue

2

Page

17-29

Document Type

Article

Frequency

semi-annually

Physical Description

graphs ; table

Language

English

En – AGROVOC descriptors

TURBINARIA ORNATA; SEAWEEDS; MARINE PLANTS; ALGAE; MONOPHENOL MONOOXYGENASE; MELANINS; POLYPHENOLS; BIOPROSPECTING

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