Nanodelivery system based on zein-alginate complexes enhances in vitro chemopreventive activity and bioavailability of pomelo [Citrus maxima (Burm.) Merr.] seed limonoids

Abstract

© 2019 Elsevier B.V. Limonin and nomilin, the major limonoid components of pomelo [Citrus maxima (Burm.) Merr.] seeds, have been reported to be potential cancer chemopreventive agents, but their low aqueous solubility and limited bioavailability impede their applications as nutraceuticals. In this study, a zein-alginate encapsulation system was utilized to produce highly dispersible limonin and nomilin nanoparticles (172.7 ± 7.4 and 273.3 ± 2.3 nm dia., respectively) with high encapsulation efficiencies and high stabilities at both ambient and refrigerated storage conditions. In vitro release studies showed that the nanodelivery system can delay and minimize the release of the limonoids in simulated gastric fluid (SGF) and preferentially release these compounds in simulated intestinal fluid (SIF). Furthermore, zein-alginate encapsulated limonin and nomilin exhibited significantly improved glutathione S-transferase (GST)-inducing activity, free radical-scavenging activity, and anti-angiogenic activity. These results demonstrate that the zein-alginate complexes can serve as effective oral delivery system for limonin and nomilin.

Source or Periodical Title

Journal of Drug Delivery Science and Technology

ISSN

17732247

Document Type

Article

Subject

Cancer chemoprevention, Delivery systems, Food waste recovery, Limonoids, Nanochemoprevention, Nutraceuticals

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